Curcumin may be effective against the development of malignant mesothelioma
July 07, 2015 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Malignant mesothelioma is a thin-film tumor that surrounds the surface of organs in the lungs, heart, and abdomen. There are currently no effective therapies to treat this cancer. Researcher Professor Sonja Klebe said that the standard chemotherapy regimen has a limited success rate, and radical surgery is only suitable for a small number of patients, and does not guarantee success every time. The average survival time of patients with malignant mesothelioma after diagnosis is less than one year, and the current treatment of this patient often makes the patient very painful.
Curcumin has long been considered to have significant anti-inflammatory effects, and recent researchers have found that curcumin has anti-cancer properties that can help overcome cancer cell resistance to chemotherapy; previously researchers in the laboratory used curcumin to successfully inhibit The growth of animal model cell mesothelioma, and now researchers using curcumin can successfully inhibit the development of human mesothelioma, which may help predict whether patients will benefit from this new type of curcumin therapy.
In addition, the researchers also found that curcumin affects the blood supply of the tumor. Traditionally, neovascularization is thought to be able to germinate from the interstitial blood vessels surrounding the tumor, and vascular endothelial growth factor can promote the process. Occurrence, while mesothelial cells can also display vascular endothelial growth factor receptors, so far, drugs targeting vascular endothelial growth factor have not achieved therapeutic success.
Researcher Klebe said that for the first time in this article we found that mesothelioma cells themselves can form 3-dimensional catheters, which may help explain the poor efficacy of standard drug treatments, that is, standard drugs do not target the formation of different types of tumor blood vessels. The researchers believe that curcumin plays an important role in angiogenesis in mesothelioma, especially curcumin has a direct effect on tumor growth.
Curcumin is usually presented in the form of an oral tablet. In fact, it does not have any side effects. It can also be used alone to treat patients, to help the patient's body effectively resist the development of cancer cell resistance. Of course, curcumin can also be combined with other therapies to help. Improves the body's response to therapies and reduces the amount of standardized drugs that ultimately improve the patient's quality of life.
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