Smoking is harmful to health and it is not easy to quit smoking. The Scripps Research Institute of the United States has developed a new smoking cessation method that uses an engineered enzyme to eliminate cravings with good results. Researchers published a research report on the online edition of Science Progress on the 17th, saying that mouse experiments show that the new method can not only reduce the dependence on nicotine, but also prevent the recurrence of niacin.
Many people know that smoking is harmful and they are still in danger. Studies have estimated that about 60% of those who try to smoke will eventually become smokers; and about 75% of those who quit smoking will relapse. The main reason for this is that these people have a dependence on nicotine. Therefore, reversing nicotine dependence by preventing nicotine from entering the brain in cigarettes is considered a promising strategy to quit smoking. But so far, no drugs have been developed that can effectively reduce the amount of nicotine in the blood.
This time, the new method developed by the Scripps Research Institute also uses this strategy. The researchers modified a enzyme, NicA2-J1, produced by Pseudomonas putida to optimize its potency, residence time in the blood, and other pharmacological properties in order to reduce the amount of nicotine in the blood. Mouse experiments showed that in the case of continuous administration (nicotine), the amount of nicotine in the blood of mice injected with NicA2-J1 was significantly lower than that of the control mice not injected with the enzyme, and after stopping the administration, the former The withdrawal symptoms are also less than the latter.
Further studies have shown that NicA2-J1 can reduce the compulsive demand for nicotine in addicted mice. After treatment, the mice's desire for nicotine is significantly reduced, and the possibility of recurrence after withdrawal is much lower. In addition, the acute effects of NicA2-J1 on addictive mice are benign and do not result in severe withdrawal reactions by taking drugs that rapidly block all nicotine activity.
Researchers say the new method can reduce dependence on nicotine, does not cause cravings and other serious withdrawal symptoms, acts on the blood rather than the brain, and has fewer side effects, making it a very desirable means of quitting smoking. (Reporter Liu Haiying)
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