Recently, researchers at Tokyo Women's Medical University and Shun Paradise University have jointly developed a new method to inhibit visceral transplant rejection, which has been used in kidney transplantation. With this new method, the patient does not have to take an immunosuppressive agent at all other times after the surgery, and the method does not cause side effects.
The major media in Japan, such as the Yomiuri Shimbun and the Asahi Shimbun, reported on the technology.
According to reports, Japanese researchers have carried out long-term research with a lymphocyte cell , the "T cell" as the target. T cells are mainly responsible for human immunity, and T cells will attack them after discovering foreign bodies such as viruses and bacteria. In the case of organ transplantation, the transplanted internal organs are also attacked by T cells as foreign bodies, which is the rejection reaction. If the rejection is severe, the transplanted organ will not work. This time, Japanese researchers have developed a special antibody that allows T cells to "missed" transplanted organs into organs. After more than five years of experiments in animals such as monkeys, the researchers finally determined that this method can effectively inhibit rejection.
According to this new method, before the transplant surgery, the medical staff will collect T cells from the blood of the patient and the organ provider, mix the two, and then put them together with special antibodies for two weeks, then input them. The patient's body. This modified T cell acts as a regulator in the patient's body, affecting other T cells, and causing a "misidentification" chain reaction. On the other hand, the "regulated" T cells do not weaken the attack on viruses and bacteria.
In past organ transplants, patients were given immunosuppressive agents for the rest of their lives. And if you use the new method, you only need to take it after a while. After confirming that the T cells in the patient's body begin to function, the dosage can be gradually reduced, and the administration can be stopped about one month to one and a half months after the operation. Since it is not necessary to take immunosuppressive agents for a long period of time, there is no need to worry about side effects such as renal dysfunction, and chronic rejection such as arteriosclerosis that often occurs in the months after surgery. According to the researchers' estimates, the proportion of the kidneys still functioning after 10 years of surgery will increase by 20% to 90%.
The researchers said that in addition to kidney transplantation, this new method can also be applied to the transplantation of organs such as heart and liver. However, the medical circles in Europe and the United States have been suffering from chronic rejection of heart transplantation, so the success of the new method will be It may have a major impact on the entire world of transplant medicine.
Core Keywords: Visceral Transplantation Lymphocyte
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