Researchers in Australia and the United States have recently discovered that a specific protein is present in the urine of patients with amyotrophic lateral sclerosis and can be used as a biomarker to track the progression of a patient's condition.
Amyotrophic lateral sclerosis, also known as motor neuron disease, commonly known as "gradual freezing disease", is a neurodegenerative disease of unknown etiology. The main clinical manifestation is that the muscles gradually shrink and weak, and patients may eventually die from respiratory failure. There is no effective treatment for this disease. The famous physicist Hawking suffered from this disease. The Ice Bucket Challenge, which was popular all over the world a few years ago, was also designed for donations.
The medical community often uses a questionnaire to measure the efficacy of drugs for amyotrophic lateral sclerosis, in contrast to the examination of biomarkers can be more accurate. Although researchers have tried to find biomarkers in the blood or cerebrospinal fluid that reflect the progression of the disease, they have not been realized. Researchers at Flinders University in Australia and the University of Miami in the United States reported in a new issue of Neurology that they found a protein called p75ECD in the urine of patients with amyotrophic lateral sclerosis. It will change as the disease progresses, so it can be used as a biomarker so that researchers can keep abreast of the patient's condition.
Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
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Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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