Release date: 2013-05-31
Japanese researchers reported on the 29th that they combined insulin-producing islet cells with proliferating stem cells to form a new cell that significantly improved the symptoms of rats after transplantation into rats with severe diabetes. .
In general, diabetes caused by insulin deficiency can be treated by transplanting islets if it is severe to a certain extent. However, in order to obtain sufficient effects, islets of multiple donors are required, and thus the problem of islet deficiency is long-term.
The research team led by Associate Professor Yooichiro Ichiro of Kyoto University reported in the online journal "Public Science Library Comprehensive Volume" that compared with the simple transplantation of islets, the method developed by them can continue to secrete insulin for a long time, and the effect is better. It is expected to be developed in the future. New treatments for diabetes.
The stem cells extracted by the researchers are mesenchymal stem cells in rat bone marrow, and their ability to proliferate and to suppress cell death is very strong. This stem cell fuses with islet cells to form a new cell. After transplanting this new cell in rats with severe diabetes, the blood glucose level continued to decrease over a period of about 3 months. If only the same number of islet cells are transplanted, the blood glucose level of the rat will hardly decrease.
Next, the research team is also preparing to use animals such as pigs to investigate whether the fusion cells are at risk of cancer. Satoro Ichiro said that if this technology can be applied to the clinic in the future, then a few providers of islets can treat many people with diabetes.
Source: Xinhuanet
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