Recently, Zhang Zhigang, the National Key Laboratory of Oncogenes and Related Genes of the Shanghai Institute of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and Xia Qiang, deputy dean of Renji Hospital and director of liver surgery, jointly led the team in the internationally renowned medical journal. Online research paper published in Gastroenterology reveals for the first time that Rac-GTPase-activating protein 1 (RACGAP1) is a key gene for up-regulation and control of tumor cell growth in human cancer, demonstrating that RACGAP1 promotes hepatoma cells by regulating Hippo pathway The molecular mechanism of mitosis and growth provides a new interpretation of the mechanism of liver cancer progression, providing new ideas and potential targets for targeted therapy of liver cancer.
An important feature of tumor cells is abnormal cell cycle. Although traditional targeted tubulin chemotherapy drugs can effectively kill tumor cells, they have serious toxic side effects. At present, newer drugs targeting cell division are not very effective in clinical trials of solid tumors. Some studies in recent years have shown that targeting tumor cell division in the late stage, especially cytokinesis, may be a more effective treatment strategy, but what are the key regulatory proteins in the process of tumor cell cytokinesis and the mechanism of action is not yet clear.
Liver tissue has a distinctive feature - the dual or multinuclear nature of liver cells. ≤50% of liver cells in adults are binuclear cells with normal physiological functions, and their formation is mostly due to cytokinesis failure. The majority of liver cancer cells are diploid cells, and their proliferation is highly dependent on cytokinesis. These backgrounds suggest that inhibition of cytokinesis is likely to inhibit the growth of liver cancer cells without affecting normal hepatocyte function.
Using the Oncomine database to explore genes that are up-regulated in human cancer, the researchers found that cytokinesis-related proteins changed most significantly, with RACGAP1 ranking first. Further in-depth studies have found that RACGAP1 promotes cytokinesis and proliferation of tumor cells by modulating the RhoA-F-actin-Hippo signaling axis to activate the transcriptional cofactor YAP. The authors also revealed for the first time that YAP can regulate the expression of nuclear pore-associated protein TPR. In the process of cell division, after the nuclear membrane is disintegrated, TPR can form a complex with RACGAP1 and Aurora kinase B, promoting the phosphorylation of RACGAP1 and the positioning of the intermediate spindle. Promotes cytokinesis and tumor growth. Given the unique function of RACGAP1 in cytokinesis and the tolerance of hepatocytes to inhibition of cytokinesis, RACGAP1 is expected to be a new target for the treatment of liver cancer. (Special correspondent Yuan Wei correspondent Xu Wei)
Source: Health News
We are a professional Chinese supplier of Skin Whitening Material; we supply various products of Whitening Material ; and we can providing product images and basic parameters with each Natural Skin Whiten Ingredients,Anti Skin Dull Ingredients and Chalkiness Ingredients. Look forward to your cooperation!
Whitening Material,Natural Skin Whiten Ingredients,Alpha-Arbutin Powder,L-glutathione Powder,Glabridin Powder
Xi'an Quanao Biotech Co., Ltd. , https://www.quanaobiotech.com