Bacterial antibiotic resistance research has made a major breakthrough

Medical Network November 16 News When bacteria evolved a special mechanism to deal with bacterial infections, it indicates the beginning of bacterial antibiotic resistance; recently, an article published in the international journal Nature Communication entitled "The In a study of multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity, researchers from the University of Birmingham in the United Kingdom conducted a study on E. coli to elucidate the novel molecular mechanisms by which bacteria protect themselves against antibiotic killing.

E. coli can induce urinary tract and bloodstream infections; in this study, with the help of new experimental techniques (including genome-wide DNA sequencing technology, etc.), researchers have identified novel mechanisms or strategies for bacteria to protect themselves against Antibiotics. Researcher David Grainger said that we found a special gene in E. coli that may be involved in the resistance of bacteria to multiple antibiotics.

Although this genetic researcher has been familiar with it for many years, it is still difficult for researchers to clarify how the gene mediates the tolerance of bacteria to antibiotics. In the article, the researchers discovered a key role that the gene has not previously elucidated, namely, the ability to control bacterial resistance to antibiotics. The researchers point out that we have discovered two completely unexpected mechanisms by which bacteria can use themselves to protect themselves from the effects of antibiotics, one of which protects bacterial DNA from the harmful effects of fluoroquinolone antibiotics, another mechanism It can inhibit the entry of antibiotics called doxycyline into bacterial cells.

Researcher Prateek Sharma said that after a lot of experimental work, we found that the bacterial resistance mechanism we identified is actually present in many different bacterial cells, which may hope to help researchers develop new drugs for effective treatment. A variety of bacterial infections. Antibiotics now support the advancement of modern medicine, veterinary and global agriculture. However, with the increasing resistance of bacteria, many antibiotics have been unable to perform their original therapeutic effects.

Later researchers will also understand the molecular mechanism of bacterial resistance through more in-depth research. At the same time, this study also provides new research clues and foundations for the later development of new drugs to resist bacterial resistance and bacterial infection.