New hope for treating AIDS
June 23, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, researchers at the VA Medical Center in San Francisco (SFVAMC) conducted a new study on AIDS. The pharmacological effects of the immune system of AIDS patients can help patients eliminate HIV-infected cells. This study provides important information for the treatment of AIDS. .
This study identified potential HIV storage pool locations for patients undergoing antiretroviral therapy. The potential HIV storage pool is built at the earliest stage of HIV infection in patients, when the patient is infected with HIV but does not produce a virus. Although antiretroviral therapy can reduce HIV in the blood to a small amount (a level that medical treatment cannot detect), the HIV virus storage pool still exists. If latently infected cells are reactivated, the cells begin to produce HIV. For this reason, antiretroviral treatment does not cure AIDS.
According to the study, the latent state of HIV depends on the inhibition of the immune system. Studies have shown that retinoic acid can stimulate the innate immune system to eliminate HIV-infected cells. In particular, vitamin A acid (a retinoic acid derivative approved by the US Food and Drug Administration) can promote the transfer of HIV into an HIV storage pool and promote the innate immune system to target HIV-infected cells.
"The current HIV treatment model can help patients control symptoms and improve their quality of life, but it can't cure AIDS," said Peili Li, MD. “AIDS patients who want to survive must receive antiretroviral drugs, and this treatment often causes side effects to patients.â€
"It's important to strengthen the body's defense against the virus. This will help antiretroviral drugs work in the human body," says Peiliin Li. "We want the immune system to recognize and kill the virus. By boosting the immune response, the body can kill cells that still produce HIV in potential HIV storage pools."
Dr. Li hopes that the results of this study will lead to new ways to treat AIDS. “I think this can open up a new direction in the fight against AIDS. Through further research we can create a clinical solution that can improve the function of the immune system and find a lasting way to treat this disease. This is a patient The central approach to HIV treatment is not only to treat symptoms, but ultimately to restore health to the patient.
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