Photoacoustic imaging: the perfect combination of optical and ultrasound imaging

---Endra small animal photoacoustic imaging system in the fields of tumor, blood vessel, brain science, etc.

Photoacoustic imaging is a non-destructive medical imaging method developed in recent years. It combines the high contrast characteristics of pure optical imaging with the high penetration depth of pure ultrasound imaging to provide high resolution and high contrast tissue imaging.

Principle of photoacoustic techniques When a beam is irradiated onto a biological tissue, the biological tissue absorbing light energy and generating thermal expansion, associated with the ultrasonic wave generating thermal expansion will absorb much of the light energy decision the intensity of the ultrasonic wave generated. Therefore, different organizations will generate different intensity of ultrasonic wave can be divided into normal tissue and lesions to tissues region. It is because of this a special point, photoacoustic techniques have a broad application prospects in medicine. The maximum advantage of the photoacoustic technique is not pre-treated sample can be directly measured to carry out the photoacoustic signal magnitude and phase, is not only easy to operate and can be shaped to maintain the natural state of the biological sample, can be carry out in vivo detection. The photoacoustic technique should be used very widely, of which medicine should be the most important.

The biggest advantage of the photoacoustic tomography is of high resolution and high contrast, very different especially when the portions of the absorption and scattering coefficients of the tissue, when the difference, it is possible to achieve better results. Especially the absorption and scattering properties of hemoglobin in the organization are very good, so photoacoustic imaging is particularly good for imaging blood vessels, either for direct diagnosis of vascular disease, or diseased tissue surrounding the blood vessel imaging, has effective.

The small animal photoacoustic imaging system developed by Endra of the United States has a nanomolar sensitivity and a high resolution of 280um to detect the epidermis. 20mm The following photoacoustic signals. It can also be used for quantitative analysis of molecular imaging of small animals. At the same time, it combines near-infrared detection technology to achieve both endogenous structure imaging and higher contrast images with the aid of contrast enhancers. It can be applied to various research fields such as tumor biology and brain neurobiology to provide more reliable and comprehensive experimental data for your research.

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