Release date: 2017-12-14
Recently, a research report published in the International Journal of Clinical Investigation, researchers from the University of California, San Diego, found that the pathway called PUMA may be a weak link in the process of breast cancer metastasis.
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At present, researchers have obtained a large number of substantive research results, which is expected to improve the rate of chemotherapy, radiotherapy and surgical treatment of primary breast cancer; however, breast cancer cells will still spread and transfer to other parts of the body, which is for researchers. It may be a big challenge. It is difficult for researchers to predict whether tumors will recur or metastasize. Of course, they are not sure whether they will have inadequate or excessive treatment.
Cells that turn on cancer metastasis are often very similar to mammary stem cells (MSCs), a healthy cell population that promotes mammary gland development in adulthood; when in pregnancy, hormone signals activate health Stem cells, open the remodeling of the breast to promote the secretion of milk. In this study, the researchers used the activation characteristics of breast stem cells to identify the weakness of stem cell-like metastatic cancer metastatic cells.
When the subject was followed for 10 years, the researchers found that the low level of PUMA protein in the body can effectively distinguish stem cell-like cells in the body of cancer patients, PUMA is p53 positive apoptosis regulator. The ability of cells to inhibit PUMA is critical for survival-enhanced PUMA expression, which also selectively knocks out stem cell-like properties and reduces cancer cell metastasis, while reducing PUMA expression restores the ability of cultured cells to metastasize.
This study clarifies a weakness in malignant breast cancer, which may be expected to help researchers effectively identify breast cancer metastasis and develop new strategies for better targeting of breast cancer in the later stages; current limitations in predicting and eliminating malignant cancer cells Sex may lead to increased mortality in patients with metastatic breast cancer, and based on the results of this study, researchers may be expected to develop new therapies targeting the weakness of metastatic breast cancer cells to effectively improve the prognosis of cancer patients. (Bio Valley Bioon.com)
Original source:
Qi Sun, Jacqueline Lesperance, Hiromi Wettersten, et al. Proapoptotic PUMA aims stem-like breast cancer cells to suppress metastasis. Journal of Clinical Investigation (2017). DOI: 10.1172/JCI93707
Source: Bio Valley
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