Release date: 2007-03-22
Recent advancements in the study of antidepressant effects of traditional Chinese medicine (TCM) have sparked growing interest among researchers. While modern treatment for depression primarily relies on synthetic pharmaceuticals, many patients experience significant side effects over time, leading to treatment discontinuation. This has prompted a search for alternative treatments, particularly from natural sources like TCM, which offer potential for safer and more effective options.
Several single-herb formulations have shown promising results in combating depressive symptoms. For example, studies on Morinda officinalis, also known as "Bai Zhu," have revealed its antidepressant properties. Research conducted by Zhang Zhongqi at the Academy of Military Medical Sciences demonstrated that extracts from this herb exhibited effects similar to those of desipramine in rat models, showing potential as an alternative treatment. Other studies found that ethanol extracts of Morinda officinalis also had comparable antidepressant effects, suggesting a broad range of therapeutic applications.
Hypericum perforatum, commonly known as St. John’s Wort, has also been extensively studied. Xu Jinghua from Shenyang Pharmaceutical University found that doses of 150 mg/kg and 300 mg/kg significantly reduced immobility time in mice during forced swimming and tail suspension tests. The herb also showed effectiveness in counteracting reserpine-induced hypothermia and eyelid drooping, indicating its potential as a natural antidepressant.
Other herbs such as Acorus calamus (Shichangpu), Centella asiatica, and others have also been explored. Li Mingya from Guangdong College of Pharmacy reported that Shichangpu decoction shortened immobility time in mouse tail suspension tests, though its effect was slightly weaker than fluoxetine. Similarly, Chen Yao from the Second Military Medical University found that Centella asiatica extract reduced immobility in rats, with oral administration showing better results than intraperitoneal injection.
In addition to single herbs, classic TCM formulas have also shown promise. Ganmai Dazao Decoction, for instance, was evaluated by Wu Jianming at Wannan Medical College. The study involved 54 patients diagnosed with depression, and the results showed a 67.9% effective rate, comparable to fluoxetine's 65.4%. Notably, the herbal formula had fewer adverse effects, making it a safer option.
Further research by Zhang Youzhi at Beijing University of Traditional Chinese Medicine confirmed the antidepressant effects of several formulas, including Chaihu Jia Longgu Mu Li Tang, Lily Dihuang Decoction, and Ganmai Dazao Decoction. These were tested in mouse forced swimming experiments, with Chaihu Jia Longgu Mu Li Tang showing the most significant effects. Additional chronic stress studies in rats reinforced these findings, highlighting the long-term benefits of such formulations.
Studies by Fu Qiang and Meng Haibin from China Pharmaceutical University further supported the efficacy of Chaihu Jia Longgu Mu Li Tang. They observed that the formula reduced immobility in mice and improved 5-HTP-induced behaviors, suggesting a link between its antidepressant effects and serotonin levels. Meanwhile, Li Jianmei from Nanjing University explored Banxia Houpu Decoction and found that it increased sucrose intake in chronic mild stress (CMS) models, indicating its potential to restore biochemical balance in depressed animals.
Overall, the growing body of research on TCM-based antidepressants suggests that these natural remedies may offer valuable alternatives or complementary treatments for depression. As more clinical trials are conducted, the integration of TCM into modern mental health care could provide new hope for patients seeking safer and more holistic approaches. Source: China Medical News
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